Betadex Sulfobutyl Ether Sodium
Injection-grade Betadex Sulfobutyl Ether Sodium (SBE-β-CD, CAS 182410-00-0), DS 6.2–6.9, supplied wholesale by Zyntex. Cyclodextrin excipient that solubilizes poorly soluble APIs in injectable, oral and inhaled products. CoA and SDS.
Description
Betadex Sulfobutyl Ether Sodium Product Overview
Betadex sulfobutyl ether sodium is beta-cyclodextrin in which, on average, about 6.2–6.9 hydroxyl groups carry sulfobutyl ether groups as sodium salts. It is a white amorphous, highly hygroscopic powder that dissolves in water at over 500 g/L.
Its ring-shaped molecule forms inclusion complexes: a lipophilic drug molecule fits into the cavity, while the charged, water-soluble exterior keeps the complex in solution. Pharmaceutical companies use it to solubilize and stabilize APIs in injectable products, such as Voriconazole, Posaconazole and Remdesivir, and in some oral and inhaled formulations.
Because it is used in injections, the degree of substitution, residual beta-cyclodextrin, endotoxins and impurity profile are key quality parameters. Zyntex supplies it from qualified excipient producers, only to licensed pharmaceutical companies.
Key Applications of Betadex Sulfobutyl Ether Sodium
Main application areas:
💉 Injectable Formulations
Solubilizer for poorly soluble APIs in injections.
💊 Oral Products
Solubility enhancer in oral formulations.
🌬️ Inhaled Products
Excipient for inhalation solutions.
🔬 Formulation Development
Cyclodextrin for solubility screening.
Betadex Sulfobutyl Ether Sodium Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | Betadex Sulfobutyl Ether Sodium |
| CAS Number | 182410-00-0 |
| Standard Grade | USP / EP (Pharma Injection Grade / Excipient) |
| Average Degree of Substitution | 6.2 – 6.9 |
| Appearance | White to almost white amorphous powder; highly hygroscopic |
| Solubility | Freely soluble in water (approx. 500 g/L at 20°C); practically insoluble in ethanol |
| Documents | CoA and SDS with every lot |
⚠️ Safety & Handling: Not classified as hazardous under GHS. Avoid dust formation and contact with eyes. Store in tightly closed containers in a dry place, because the powder is highly hygroscopic. Always consult the Safety Data Sheet (SDS) for full classification and handling instructions.
Frequently Asked Questions
How does SBE-β-cyclodextrin improve solubility?
It forms inclusion complexes in which the drug molecule sits inside the cyclodextrin cavity, while the water-soluble exterior keeps the complex dissolved.
Is it suitable for injections?
Yes, injection-grade material with controlled endotoxins and degree of substitution is supplied for parenteral use.
How can I get a price and documents?
Prices depend on quantity, packaging and destination. Contact us with your required volume to receive a quotation together with the CoA and SDS.
